Makrozomik fetuslar 38. gebelik haftasında doğurtulabilir mi?

Objective: Numerous articles have been written on macrosomic fetuses, including the American College of Obstetricians and Gynecologists practice bulletin. However, there is no clear consensus about the time of birth. The aim of this study was to compare the maternal and fetal outcomes of women giving birth at 38+0-38+6 weeks and those with deliveries at ≥39 weeks in pregnancies complicated by fetal macrosomia, and to determine the effect on morbidity and mortality of delivery in the 38th gestational week.Material and Methods: Data of women and their infants born in Kayseri Training and Research Hospital between 01 May 2018 and 31 March 2020 were analyzed retrospectively. The patients included were those with a singleton pregnancy delivered at ≥38 weeks with a birthweight of ≥4000 gr. Demographic data and medical history and birth outcomes of the patients were recorded from the hospital data system. Multiple pregnancies, those with fetal anomalies and births <38 weeks were excluded from the study. The patients were separated into two groups as those who gave birth at 38+0-38+6 gestational weeks (Group 1) and those who gave birth at ≥39 weeks (Group 2).Results: Maternal and/or fetal trauma was found to be statistically significantly higher in nulliparous women with vaginal delivery ≥39 weeks compared to those with vaginal delivery at 38+0-38+6 weeks (p=0.017). No significant difference was observed between the groups in respect of fetal morbidity and mortality.Conclusion: When fetal macrosomia is determined antenatally, rates of fetal and/or maternal trauma can be reduced with delivery planned for the 38th week without increasing fetal morbidity and mortality.Amaç: Makrozomik fetüsler hakkında, Amerikan Obstetrik ve Jinekoloji Derneğinin bültenleri de dahil olmak üzere çok sayıda makale yazılmıştır. Ancak doğum zamanı konusunda net bir fikir birliği yoktur. Bu çalışmanın amacı fetal makrozomi ile komplike gebeliklerde 38+0-38+6 hafta arasında doğum yapan kadınlar ile ≥39 hafta sonrasında doğum yapan kadınların maternal ve fetal sonuçlarını karşılaştırmak ve doğum haftasının 38. haftaya çekilmesinin yenidoğanın morbidite ve mortalitesini etkileme düzeyini belirlemektir.Gereç ve Yöntemler: Bu retrospektif çalışmada, 01 Mayıs 2018-31 Mart 2020 tarihleri arasında Kayseri Eğitim ve Araştırma Hastanesinde doğum yapan kadınların ve bebeklerinin verileri geriye dönük olarak tarandı. Doğum ağırlığı ≥4000 gram, tekil, ≥38 hafta üzerinde doğum yapan hastalar çalışmaya dâhil edildi. Hastaların demografik ve medikal öyküleri ve doğum sonuçları hastane veri sisteminden kayıt edildi. Çoğul gebelikler, fetal anomaliler ve <38 gebelik haftasındaki doğumlar çalışma haricinde tutuldu. Hastalar 38+0- 38+6 hafta arasında doğum yapanlar (Grup 1) ve ≥39 haftada doğum yapanlar (Grup 2) olarak iki gruba ayrıldı.Bulgular: ≥39 haftadan sonra vajinal doğum yapan (grup 2) nullipar kadınlarda maternal veya fetal travma 38+0 - 38+6 (grup 1) hafta arasında vajinal doğum yapan nullipar kadınlara oranla istatistiksel anlamlı olarak yüksek bulundu (p=0.017). İki grup arasında fetal morbidite ve mortalite incelendiğinde gruplar arasında anlamlı farklılık izlenmedi.Sonuç: Doğum öncesi değerlendirmede fetal makrozomi saptanan gebelerde fetal ve/veya maternal travma oranları, fetal morbidite ve mortalite arttırılmadan 38. haftada planlanacak bir doğum ile azaltılabilir

Elicitation of the factors affecting electricity distribution efficiency using the fuzzy AHP method

Efficient and uninterrupted energy supply plays a crucial role in the quality of modern daily life, while it is obvious that the efficiency and performance of energy supply companies has a significant impact on energy supply itself and on determining and finetuning the future roadmap of the sector. In this study, the performance and efficiency of energy supply companies with respect to productivity is investigated with reference to a case study of an electricity distribution company in Turkey. The factors affecting the company’s performance and their corresponding weight have been determined and obtained using the analytical hierarchy process (AHP) and the Fuzzy AHP methods, two well-known multi-criteria decision-making methods, which are widely used in the literature. The results help demonstrate that the criteria obtained to evaluate the company’s energy supply performance play a crucial role in developing strategies, policies and action plans to achieve continuous improvement and consistent development

Antinociceptive and anxiolytic-like effects of some compounds carrying benzothiazole ring

Bu çalışmanın amacı benzotiyazol halkası taşıyan bazı bileşiklerin antinosiseptif ve anksiyolitik-benzeri etkilerinin incelenmesidir. 40 mg/kg dozda uygulanan test bileşiklerinin antinosiseptif etkileri kuyruk sıkıştırma, sıcak plaka ve asetik asid ile indüklenen kıvranma testleri ile araştırılmıştır. Bileşiklerin anksiyolitik-benzeri etkilerini incelemek için delikli tahta ve yükseltilmiş artı labirent testleri gerçekleştirilmiştir. Farelerin motor koordinasyonlarını değerlendirmek üzere Rota-rod cihazı kullanılmıştır. Deneyler sonucunda 3f, 3g ve 3h kodlu bileşiklerin kuyruk sıkıştırma ve sıcak plaka testlerinde hayvanların reaksiyon sürelerini artırdığı ve 3e kodlu bileşiğin ise asetik asid ile indüklenen kıvranma testinde farelerin kıvranma sayılarını azalttığı belirlenmiştir. Diğer yandan, 3f, 3g ve 3h kodlu bileşikler delikli tahta testinde farelerin ilk baş daldırma sürelerini kısaltırken toplam baş daldırma sayılarını artırmıştır. Yükseltilmiş artı labirent testinde ise aynı türevlerin farelerin açık kola giriş sayılarının ve açık kolda kalma sürelerinin yüzdelerini artırdığı ortaya konulmuştur. Rota-rod testlerinde test bileşikleri farelerin dönen milden düşme sürelerini değiştirmemiştir. Tüm bu bulgular, 3f, 3g ve 3h kodlu bileşiklerin santral antinosiseptif ve anksiyolitik-benzeri etki gösterdiklerine; 3e kodlu bileşiğin ise periferal antinosiseptif etki gösterdiğine işaret etmektedir.The aim of this study was to examine the antinociceptive and anxiolytic-like effects of some compounds carrying benzothiazole ring. The antinociceptive effects of test compounds, administrated at a dose of 40 mg/kg, were investigated by tail clip, hot plate and acetic acid-induced writhing tests. Hole board and elevated plus maze tests were performed to evaluate the anxiolytic-like effects of the compounds. Rota-rod device was used to assess the motor coordinations of mice. As a result of the experiments, it was determined that compounds 3f, 3g and 3h increased the reaction times of animals in the tail clip and hot plate tests, and compound 3e reduced the writhing number of mice in the acetic acid-induced writhing test. On the other hand, in the hole board test, compounds 3f, 3g and 3h reduced the first head-dipping latencies of mice while increasing the total number of head-dips. In the elevated plus maze test, it has been shown that the same derivatives increase the percentages of open arm entries and time spent in the open arms. In the Rota-rod tests, test compounds did not change the falling time of mice from the rotating mill. All these findings point out that compounds 3f, 3g and 3h exhibit central antinociceptive and anxiolytic-like effects and compound 3e shows a peripheral antinociceptive effect

Decentralized probabilistic density control of swarm of autonomous agents with conflict avoidance constraints

textThis report describes a method to control the density distribution of a large number of autonomous agents. The approach is based on the fact that there are a large number of agents in the system, and hence the time evolution of the probabilistic density distribution of agents can be described as a Markov chain. The main contribution of this paper is the synthesis of a Markov matrix which will guide the multi-agent system density to a desired steady-state density distribution, in a probabilistic sense, while satisfying some motion and safety constraints. Also, an adaptive density control method based on real time density feedback is introduced to synthesize a time-varying Markov ma- trix, which leads to better convergence to the desired density distribution. Finally, a decentralized density computation method is described. This method guarantees that all agents will have a best, and common, density estimate in a finite, with an explicit bound, number of communication updates.Aerospace Engineerin

Input-output analysis for Adana Region.

TEZ12555Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2019.Kaynakça (s. 94-101) var.XIII, 105 s. :_res., tablo ;_29 cm.Bir bölge, şehir ya da ülkeye yönelik planlama yapılırken önce o bölgenin sosyoekonomik, tarihsel ve yapısal analizi detaylı bir şekilde ele alınmalıdır. Bölgesel kalkınma planlarının, bölge yapısıyla uyumlu olması ve ekonomik ilişkilerin yönünün ve boyutunun doğru tespit edilmesi son derece önemlidir. Bu bağlamda, Girdi-Çıktı analizleri, sektörlerin karşılıklı etkileşimlerini ve birbirlerine bağımlılıklarını dikkate alması bakımından, detaylı yapısal analizlere imkân sağlamaktadır. Bu tezde, Adana Bölgesi için Girdi-Çıktı analizi yapılarak, bölgede faaliyet gösteren 69 sektör belirlenmiştir. Analiz yapılırken, önce birim matris, sonrasında teknik katsayılar matrisi, ardından da Leontief ters matrisi hesaplanmıştır. Analiz sonucunda Hirschman kategorisine göre 18 adet kilit sektör saptanmıştır. Çalışma kapsamında hesaplanan katsayılar yardımıyla Adana’nın endüstriyel bağınlaşma yapısı ortaya koyulmuş, bölgesel planlamada kullanılabilecek önemli göstergeler tespit edilmiştir. Tezde kullanılan veriler, T.C. Sanayi ve Teknoloji Bakanlığı Girişimci Bilgi Sistemi’nden temin edilmiştir ve sistemdeki en güncel veri yılı olan 2017 yılına aittir.In order to make a plan for a region, city or country, first the socio-economic, historical and structural analysis of that region should be considered in detail. It is extremely important that regional development plans are coherent with the regional structure and that the direction and dimension of economic relations are determined correctly. In this context, Input-Output analyzes allow detailed structural analyzes in terms of taking into account the interactions and interdependence of sectors. In this thesis, by making Input-Output analysis for Adana Region, 69 sectors operating in the region have been identified. During the analysis, first the unit matrix, then the technical coefficients matrix and then the Leontief inverse matrix were calculated. As a result of the analysis, 18 key sectors were identified according to Hirschman category. With the help of the calculated coefficients, the industrial correlation structure of Adana region has been revealed. And important indicators that can be used in regional planning have been identified. The data used in the thesis was obtained from, Entrepreneur Information System which is the subunit of Turkish Republic Ministry of Industry and Technology. The data is from 2017 which is the most recent data year in the system

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

Aim: To determine the factors in the etiology of recurrent aphthous stomatitis (RAS) and to evaluate patients in the terms of RAS associated systemic disorders especially Behçet’s disease. Methods: Patients with RAS, who were followed up in Bartın State Hospital Dermatology Clinic between July 2013 and April 2015, were retrospectively evaluated. Results: A total of 123 patients (86 female, 37 male) were included in this study. Thirteen (106%) patients were children. The mean age of patients was 34.5±14.7 years (range: 8-69 years). Minor aphthous somatitis was the most frequent clinical type (68.3%). Family history was positive in 52.8% of patients. The triggering factors in the etiology of RAS were stress (54.5%), trauma (40.2%), gingivitis (29.3%), food (9.8%), medicines (5.7%), menstruation in female patients (3.3%), and throat infections (2.4%). Nutritional deficiencies were found in 39% of patients. There was a statistically significant difference in attack frequency (p=0.017) and throat infection history (p=0.029) between adults and pediatric patients. Fourteen (11.4%) patients were diagnosed with Behçet’s disease. When we compared the RAS patients diagnosed with Behçet’s disease and the other RAS patients, a significant difference was found in pathergy test (p<0.001) and ferritin levels (p=0.020). Conclusion: Patients with RAS should be followed up for a long time for systemic disorders, especially for Behçet’s disease, accompanying RAS

Pendimetalinin Genotoksik Etkilerinin Çin Hamster Over Hücrelerinde Tek Hücre Jel Elektroforez (Comet) Yöntemiyle Değerlendirilmesi

Objectives: Pendimethalin (N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzeneamine) is a dinitroaniline herbicide compound which selectively controls weeds. It is a cell division and growth inhibitor. It descends plants in a short time after seedling. It is a soil and water pollutant due to the widespread use of formulations in Turkey and around the world. Pendimethalin is manufactured in and imported by Turkey. Pendimethalin is a slightly toxic compound that is classified in toxicity class 3 by the United States Environmental Protection Agency (USEPA). Even though it is classified as group C (human possible carcinogen) compound by the USEPA, there are limited number of studies about its genotoxic effects. The aim of this study was to evaluate in vitro genotoxic effects of different concentrations of pendimethalin in Chinese hamster over (CHO) cells by the single cell gel electrophoresis (comet) assay. Materials and Methods: The cells are incubated with 1, 10, 100, 1000 and 10000 µM concentrations of pendimethalin for 30 min at 37°C and DNA damage was compared with CHO cells untreated with pendimethalin. 50 µM hydrogen peroxide was used as positive control. Results: No significant cytotoxic effects were observed within the concentration ranges studied. The DNA damage in CHO cells was significantly increased in the pendimethalin concentrations of 1, 100, 1000 and 10000 µM, however, a significant decrease was observed in 10 µM pendimethalin concentration. Conclusion: Our results show that 1-10000 µM concentrations of pendimethalin induce DNA damage in CHO cells, which was assessed by comet assay.Scopu

The Investigation of Relationship between Functional Mobility Levels of Children with Chronic Disability and Caregivers’ Quality of Life

Purpose: This study aims to look at the relationship between carers' quality of life and the functional mobility levels of children with chronic disabilities.Methods: The study included 30 children (22 boys, 8 girls) with chronic disabilities and their caregivers. The socio-demographic characteristics of the children and caregivers were collected.Caregivers' quality of life was evaluated with the Adult Carer Quality of Life Questionnaire (AC-QoL), and children’s functional mobility was evaluated with the mobility subscale of the Pediatric Evaluation Of Disability Inventory (PEDI-Mobility). Results: The age of the children included in the study was 7.0 (5.0-12.0) years and the age of their caregivers was 38.00 (32.75-41.25) years. The AC-QoL score of caregivers was 85.00 (72.00-93.50) out of a total of 120 points, and the PEDI-Mobility score was 33.00 (3.75-53.00) out of a total of 58 points. In the correlation analysis, no significant correlation was found between the PEDI-Mobility total score and the AC-QoL total score (p>0.05).However, there was a negative correlation between the PEDI-Mobility total score and the AC-QoL “ability to care” subscale score(r= -0.403; p=0.027). Conclusion: According to the results of the study, no relationship was found between the functional levels of children and the quality of life of their caregivers. Studies with a larger sample size and consideration of aspects including sociocultural level, economic considerations, and health services that may affect the quality of life of families are regarded to be necessary in order to achieve more conclusive findings on this subject